Mice deficient in H+-ATPase a4 subunit have severe hearing impairment associated with enlarged endolymphatic compartments within the inner ear

• मुख्य लेखकों: Beatriz Lorente-Cánovas (लेखक), Neil Ingham (लेखक), Elizabeth E. Norgett (लेखक), Zoe J. Golder (लेखक), Fiona E. Karet Frankl (लेखक), Karen P. Steel (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: The Company of Biologists, 2013-03-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

SUMMARY Mutations in the ATP6V0A4 gene lead to autosomal recessive distal renal tubular acidosis in patients, who often show sensorineural hearing impairment. A first Atp6v0a4 knockout mouse model that recapitulates the loss of H+-ATPase function seen in humans has been generated and recently report...