Quantitative Systems Pharmacology Model of a Masked, Tumor‐Activated Antibody

• Κύριοι συγγραφείς: Mark Stroh (Συγγραφέας), Jason Sagert (Συγγραφέας), John M. Burke (Συγγραφέας), Joshua F. Apgar (Συγγραφέας), Lin Lin (Συγγραφέας), Bjorn L. Millard (Συγγραφέας), W. Michael Kavanaugh (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Wiley, 2019-09-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

PROBODY therapeutics (Pb‐Tx) are protease‐activatable prodrugs of monoclonal antibodies (mAbs) designed to target tumors where protease activity is elevated while avoiding normal tissue. They are composed of a parental mAb, a mask that inhibits antibody binding to target, and a protease‐cleavable su...