Quantitative Systems Pharmacology Model of a Masked, Tumor‐Activated Antibody

• मुख्य लेखकों: Mark Stroh (लेखक), Jason Sagert (लेखक), John M. Burke (लेखक), Joshua F. Apgar (लेखक), Lin Lin (लेखक), Bjorn L. Millard (लेखक), W. Michael Kavanaugh (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Wiley, 2019-09-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

PROBODY therapeutics (Pb‐Tx) are protease‐activatable prodrugs of monoclonal antibodies (mAbs) designed to target tumors where protease activity is elevated while avoiding normal tissue. They are composed of a parental mAb, a mask that inhibits antibody binding to target, and a protease‐cleavable su...