Protective Effect of GIP against Monosodium Glutamate-Induced Ferroptosis in Mouse Hippocampal HT-22 Cells through the MAPK Signaling Pathway

• Main Authors: Jiwon Ko (Author), Soyoung Jang (Author), Wookbong Kwon (Author), Si-Yong Kim (Author), Soyeon Jang (Author), Eungyung Kim (Author), Young-Rae Ji (Author), Sijun Park (Author), Myoung-Ok Kim (Author), Seong-Kyoon Choi (Author), Dong-Hyung Cho (Author), Hyun-Shik Lee (Author), Su-Geun Lim (Author), Zae-Young Ryoo (Author)
• Format: Book
• Published: MDPI AG, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The effect of glucose-dependent insulinotropic polypeptide (GIP) on cells under oxidative stress induced by glutamate, a neurotransmitter, and the underlying molecular mechanisms were assessed in the present study. We found that in the pre-treatment of HT-22 cells with glutamate in a dose-dependent...