Establishment of a human nasal epithelium model of histamine-induced inflammation to assess the activity of fexofenadine as an inverse agonist and its link to clinical benefit

• Main Authors: Anne Barbot (Author), Michele Lheritier-Barrand (Author), Margarita Murrieta-Aguttes (Author), Maud Leonetti (Author), Jimmy Vernaz (Author), Song Huang (Author), Samuel Constant (Author), Bernadett Boda (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundFexofenadine (FEX) is an antihistamine that acts as an inverse agonist against histamine (HIS) receptor 1 (H1R), which mediates the allergic reaction. Inverse agonists may be more potent than neutral antagonists, as they bind the same receptor as the agonist (HIS) but stabilize the inactiv...