Establishment of a human nasal epithelium model of histamine-induced inflammation to assess the activity of fexofenadine as an inverse agonist and its link to clinical benefit

• Hlavní autoři: Anne Barbot (Autor), Michele Lheritier-Barrand (Autor), Margarita Murrieta-Aguttes (Autor), Maud Leonetti (Autor), Jimmy Vernaz (Autor), Song Huang (Autor), Samuel Constant (Autor), Bernadett Boda (Autor)
• Médium: Kniha
• Vydáno: Frontiers Media S.A., 2024-06-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

BackgroundFexofenadine (FEX) is an antihistamine that acts as an inverse agonist against histamine (HIS) receptor 1 (H1R), which mediates the allergic reaction. Inverse agonists may be more potent than neutral antagonists, as they bind the same receptor as the agonist (HIS) but stabilize the inactiv...