Ligand binding properties of two Brugia malayi fatty acid and retinol (FAR) binding proteins and their vaccine efficacies against challenge infection in gerbils.

• Main Authors: Bin Zhan (Author), Sridhar Arumugam (Author), Malcolm W Kennedy (Author), Nancy Tricoche (Author), Lu-Yun Lian (Author), Oluwatoyin A Asojo (Author), Sasisekhar Bennuru (Author), Maria Elena Bottazzi (Author), Peter J Hotez (Author), Sara Lustigman (Author), Thomas R Klei (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2018-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Parasitic nematodes produce an unusual class of fatty acid and retinol (FAR)-binding proteins that may scavenge host fatty acids and retinoids. Two FARs from Brugia malayi (Bm-FAR-1 and Bm-FAR-2) were expressed as recombinant proteins, and their ligand binding, structural characteristics, and immuno...