MAB21L1 modulates gene expression and DNA metabolic processes in the lens placode

• Váldodahkkit: Ryuichi Yamada (Dahkki), Akira Oguri (Dahkki), Katsunori Fujiki (Dahkki), Katsuhiko Shirahige (Dahkki), Yoshikazu Hirate (Dahkki), Masami Kanai-Azuma (Dahkki), Hirotaka Takezoe (Dahkki), Yoshihiro Akimoto (Dahkki), Naoki Takahashi (Dahkki), Yoshiakira Kanai (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: The Company of Biologists, 2021-12-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Mutations in human MAB21L1 cause aberrations in lens ectoderm morphogenesis and lead to congenital cerebellar, ocular, craniofacial and genital (COFG) syndrome. Murine Mab21l1-null mutations cause severe cell-autonomous defects in lens formation, leading to microphthalmia; therefore, Mab21l1-null mi...