MAB21L1 modulates gene expression and DNA metabolic processes in the lens placode

• Main Authors: Ryuichi Yamada (Author), Akira Oguri (Author), Katsunori Fujiki (Author), Katsuhiko Shirahige (Author), Yoshikazu Hirate (Author), Masami Kanai-Azuma (Author), Hirotaka Takezoe (Author), Yoshihiro Akimoto (Author), Naoki Takahashi (Author), Yoshiakira Kanai (Author)
• Format: Book
• Published: The Company of Biologists, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mutations in human MAB21L1 cause aberrations in lens ectoderm morphogenesis and lead to congenital cerebellar, ocular, craniofacial and genital (COFG) syndrome. Murine Mab21l1-null mutations cause severe cell-autonomous defects in lens formation, leading to microphthalmia; therefore, Mab21l1-null mi...