MAB21L1 modulates gene expression and DNA metabolic processes in the lens placode

• 主要な著者: Ryuichi Yamada (著者), Akira Oguri (著者), Katsunori Fujiki (著者), Katsuhiko Shirahige (著者), Yoshikazu Hirate (著者), Masami Kanai-Azuma (著者), Hirotaka Takezoe (著者), Yoshihiro Akimoto (著者), Naoki Takahashi (著者), Yoshiakira Kanai (著者)
• フォーマット: 図書
• 出版事項: The Company of Biologists, 2021-12-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Mutations in human MAB21L1 cause aberrations in lens ectoderm morphogenesis and lead to congenital cerebellar, ocular, craniofacial and genital (COFG) syndrome. Murine Mab21l1-null mutations cause severe cell-autonomous defects in lens formation, leading to microphthalmia; therefore, Mab21l1-null mi...