MAB21L1 modulates gene expression and DNA metabolic processes in the lens placode

• Автори: Ryuichi Yamada (Автор), Akira Oguri (Автор), Katsunori Fujiki (Автор), Katsuhiko Shirahige (Автор), Yoshikazu Hirate (Автор), Masami Kanai-Azuma (Автор), Hirotaka Takezoe (Автор), Yoshihiro Akimoto (Автор), Naoki Takahashi (Автор), Yoshiakira Kanai (Автор)
• Формат: Книга
• Опубліковано: The Company of Biologists, 2021-12-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Mutations in human MAB21L1 cause aberrations in lens ectoderm morphogenesis and lead to congenital cerebellar, ocular, craniofacial and genital (COFG) syndrome. Murine Mab21l1-null mutations cause severe cell-autonomous defects in lens formation, leading to microphthalmia; therefore, Mab21l1-null mi...