MAB21L1 modulates gene expression and DNA metabolic processes in the lens placode

• Egile Nagusiak: Ryuichi Yamada (Egilea), Akira Oguri (Egilea), Katsunori Fujiki (Egilea), Katsuhiko Shirahige (Egilea), Yoshikazu Hirate (Egilea), Masami Kanai-Azuma (Egilea), Hirotaka Takezoe (Egilea), Yoshihiro Akimoto (Egilea), Naoki Takahashi (Egilea), Yoshiakira Kanai (Egilea)
• Formatua: Liburua
• Argitaratua: The Company of Biologists, 2021-12-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Mutations in human MAB21L1 cause aberrations in lens ectoderm morphogenesis and lead to congenital cerebellar, ocular, craniofacial and genital (COFG) syndrome. Murine Mab21l1-null mutations cause severe cell-autonomous defects in lens formation, leading to microphthalmia; therefore, Mab21l1-null mi...