Adaptive Immunity and Antigen-Specific Activation in Obesity-Associated Insulin Resistance

• Main Authors: Melissa Hui Yen Chng (Author), Michael N. Alonso (Author), Sarah E. Barnes (Author), Khoa D. Nguyen (Author), Edgar G. Engleman (Author)
• Format: Book
• Published: Hindawi Limited, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Type 2 diabetes mellitus (T2D) is a metabolic disease that is strongly tied to obesity and often preceded by insulin resistance (IR). It has been established that chronic inflammation of hypertrophic adipose tissue depots in obese individuals leads to obesity-associated IR and is mediated by cells o...