Phenotyping Indices of CYP450 and P-Glycoprotein in Human Volunteers and in Patients Treated with Painkillers or Psychotropic Drugs

• Main Authors: Léa Darnaud (Author), Clément Delage (Author), Youssef Daali (Author), Anne-Priscille Trouvin (Author), Serge Perrot (Author), Nihel Khoudour (Author), Nadia Merise (Author), Laurence Labat (Author), Bruno Etain (Author), Frank Bellivier (Author), Célia Lloret-Linares (Author), Vanessa Bloch (Author), Emmanuel Curis (Author), Xavier Declèves (Author)
• Format: Book
• Published: MDPI AG, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Drug-metabolizing enzymes and drug transporters are key determinants of drug pharmacokinetics and response. The cocktail-based cytochrome P450 (CYP) and drug transporter phenotyping approach consists in the administration of multiple CYP or transporter-specific probe drugs to determine their activit...