Evaluation of neurobiological and antioxidant effects of novel melatonin analogs in mice

• Main Authors: Jana Tchekalarova (Author), Natasha Ivanova (Author), Zlatina Nenchovska (Author), Rumiana Tzoneva (Author), Tzveta Stoyanova (Author), Veselina Uzunova (Author), Slavina Surcheva (Author), Alex Tzonev (Author), Violina T. Angelova (Author), Pavlina Andreeva-Gateva (Author)
• Format: Book
• Published: Elsevier, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Based on the pharmacophore model of melatonin (MT1) receptor, we recently synthesized a series of indole derivatives that showed anticonvulsant activity with low neurotoxicity and hepatotoxicity in rodents. In the present study, the three most potent C3-modified derivatives with hydrazine structure...