Evaluation of neurobiological and antioxidant effects of novel melatonin analogs in mice

• 主要な著者: Jana Tchekalarova (著者), Natasha Ivanova (著者), Zlatina Nenchovska (著者), Rumiana Tzoneva (著者), Tzveta Stoyanova (著者), Veselina Uzunova (著者), Slavina Surcheva (著者), Alex Tzonev (著者), Violina T. Angelova (著者), Pavlina Andreeva-Gateva (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2020-12-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Based on the pharmacophore model of melatonin (MT1) receptor, we recently synthesized a series of indole derivatives that showed anticonvulsant activity with low neurotoxicity and hepatotoxicity in rodents. In the present study, the three most potent C3-modified derivatives with hydrazine structure...