Evaluation of neurobiological and antioxidant effects of novel melatonin analogs in mice

• প্রধান লেখক: Jana Tchekalarova (লেখক), Natasha Ivanova (লেখক), Zlatina Nenchovska (লেখক), Rumiana Tzoneva (লেখক), Tzveta Stoyanova (লেখক), Veselina Uzunova (লেখক), Slavina Surcheva (লেখক), Alex Tzonev (লেখক), Violina T. Angelova (লেখক), Pavlina Andreeva-Gateva (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Elsevier, 2020-12-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Based on the pharmacophore model of melatonin (MT1) receptor, we recently synthesized a series of indole derivatives that showed anticonvulsant activity with low neurotoxicity and hepatotoxicity in rodents. In the present study, the three most potent C3-modified derivatives with hydrazine structure...