Cav3.2-dependent hyperalgesia/allodynia following intrathecal and intraplantar zinc chelator administration in rodents

• Main Authors: Shiori Tomita (Author), Fumiko Sekiguchi (Author), Katsuki Naoe (Author), Shiyu Shikimi (Author), Yoshihito Kasanami (Author), Maya Ohigashi (Author), Maho Tsubota (Author), Atsufumi Kawabata (Author)
• Format: Book
• Published: Elsevier, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cav3.2, a T-type calcium channel (T-channel) family member, is expressed in the nociceptors and spinal cord, and its activity is largely suppressed by zinc under physiological conditions. In rats, intrathecal and intraplantar administration of a zinc chelator, TPEN, caused T-channel-dependent mechan...