A System for Discovering Novel Uricosurics Targeting Urate Transporter 1 Based on In Vitro and In Vivo Modeling

• Main Authors: Xuechen Li (Author), Chufan Qi (Author), Mengjie Shao (Author), Yajun Yang (Author), Yuying Wang (Author), Jiang Li (Author), Zhiyan Xiao (Author), Fei Ye (Author)
• Format: Book
• Published: MDPI AG, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hyperuricemia has become a global burden with the increasing prevalence and risk of associated metabolic disorders and cardiovascular diseases. Uricosurics act as a vital urate-lowering therapy by promoting uric acid excretion via the kidneys. However, potent and safe uricosurics are still in urgent...