Synthesis, Antibacterial Evaluation and QSAR of α-Substituted-N4-Acetamides of Ciprofloxacin and Norfloxacin

• Main Authors: Amjad M. Qandil (Author), Lorca O. Al-Zoubi (Author), Amal G. Al-Bakri (Author), Haneen A. Amawi (Author), Qosay A. Al-Balas (Author), Abdulmalik M. Alkatheri (Author), Abdulkareem M. Albekairy (Author)
• Formato: Livro
• Publicado em: MDPI AG, 2014-06-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Twenty six α-substituted N4-acetamide derivatives of ciprofloxacin (CIPRO) and norfloxacin (NOR) were synthesized and assayed for antibacterial activity against Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus and Bacillus subtilis. The derivatives were primarily more active against G...