Antibody-epitope conjugates deliver immunogenic T-cell epitopes more efficiently when close to cell surfaces

• Autori principali: W. van der Wulp (Autore), W. Luu (Autore), M. E. Ressing (Autore), J. Schuurman (Autore), S. I. van Kasteren (Autore), L. Guelen (Autore), R. C. Hoeben (Autore), B. Bleijlevens (Autore), M. H. M. Heemskerk (Autore)
• Natura: Libro
• Pubblicazione: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

ABSTRACTAntibody-mediated delivery of immunogenic viral CD8+ T-cell epitopes to redirect virus-specific T cells toward cancer cells is a promising new therapeutic avenue to increase the immunogenicity of tumors. Multiple strategies for viral epitope delivery have been shown to be effective. So far,...