Novel H7N9 influenza immunogen design enhances mobilization of seasonal influenza T cell memory in H3N2 pre-immune mice

• Autores principales: Leonard Moise (Autor), Lauren M. Meyers (Autor), Hyesun Jang (Autor), Mayara Grizotte-Lake (Autor), Christine M. Boyle (Autor), Bethany McGonnigal (Autor), Pan Ge (Autor), Ted M. Ross (Autor), Anne S. De Groot (Autor)
• Formato: Libro
• Publicado: Taylor & Francis Group, 2022-11-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Strategies that improve influenza vaccine immunogenicity are critical for the development of vaccines for pandemic preparedness. Hemagglutinin (HA)-specific CD4+ T cell epitopes support protective B cell responses against seasonal influenza. However, in the case of avian H7N9, which poses a pandemic...