In vitro and in vivo evaluation of macromolecular prodrug GC-FUA based nanoparticle for hepatocellular carcinoma chemotherapy

• Main Authors: Can Huang (Author), Na-Mei Li (Author), Pei Gao (Author), Sa Yang (Author), Qian Ning (Author), Wen Huang (Author), Zhi-Ping Li (Author), Peng-Ju Ye (Author), Li Xiang (Author), Dong-Xiu He (Author), Xiang-Wen Tan (Author), Cui-Yun Yu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A novel type of macromolecular prodrug delivery system is reported in this research. The N-galactosylated-chitosan-5-fluorouracil acetic acid conjugate (GC-FUA) based nanoparticle delivery system was evaluated in vitro and in vivo. Biocompatibility of GC-FUA-NPs was screened by BSA adsorption test a...