Novel Use of PLGA Microspheres to Create an Animal Model of Glaucoma with Progressive Neuroretinal Degeneration

• Main Authors: David Garcia-Herranz (Author), Maria Jesus Rodrigo (Author), Manuel Subias (Author), Teresa Martinez-Rincon (Author), Silvia Mendez-Martinez (Author), Irene Bravo-Osuna (Author), Aina Bonet (Author), Jesus Ruberte (Author), Julian Garcia-Feijoo (Author), Luis Pablo (Author), Elena Garcia-Martin (Author), Rocío Herrero-Vanrell (Author)
• Format: Book
• Published: MDPI AG, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Progressive degeneration of neuroretinal tissue with maintained elevated intraocular pressure (IOP) to simulate chronic glaucoma was produced by intracameral injections of poly (lactic-co-glycolic) acid (PLGA) microspheres (Ms) in rat eyes. The right eye of 39 rats received different sizes of PLGA-M...