Design of multi-epitope peptides containing HLA class-I and class-II-restricted epitopes derived from immunogenic Leishmania proteins, and evaluation of CD4+ and CD8+ T cell responses induced in cured cutaneous leishmaniasis subjects.

• मुख्य लेखकों: Sarra Hamrouni (लेखक), Rachel Bras-Gonçalves (लेखक), Abdelhamid Kidar (लेखक), Karim Aoun (लेखक), Rym Chamakh-Ayari (लेखक), Elodie Petitdidier (लेखक), Yasmine Messaoudi (लेखक), Julie Pagniez (लेखक), Jean-Loup Lemesre (लेखक), Amel Meddeb-Garnaoui (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Public Library of Science (PLoS), 2020-03-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Human leishmaniasis is a public health problem worldwide for which the development of a vaccine remains a challenge. T cell-mediated immune responses are crucial for protection. Peptide vaccines based on the identification of immunodominant T cell epitopes able to induce T cell specific immune respo...