Design of multi-epitope peptides containing HLA class-I and class-II-restricted epitopes derived from immunogenic Leishmania proteins, and evaluation of CD4+ and CD8+ T cell responses induced in cured cutaneous leishmaniasis subjects.

• Main Authors: Sarra Hamrouni (Author), Rachel Bras-Gonçalves (Author), Abdelhamid Kidar (Author), Karim Aoun (Author), Rym Chamakh-Ayari (Author), Elodie Petitdidier (Author), Yasmine Messaoudi (Author), Julie Pagniez (Author), Jean-Loup Lemesre (Author), Amel Meddeb-Garnaoui (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Human leishmaniasis is a public health problem worldwide for which the development of a vaccine remains a challenge. T cell-mediated immune responses are crucial for protection. Peptide vaccines based on the identification of immunodominant T cell epitopes able to induce T cell specific immune respo...