Synthesis and In Vitro Assessment of pH-Sensitive Human Serum Albumin Conjugates of Pirarubicin

• Main Authors: Kenji Tsukigawa (Author), Shuhei Imoto (Author), Keishi Yamasaki (Author), Koji Nishi (Author), Toshihiko Tsutsumi (Author), Shoko Yokoyama (Author), Yu Ishima (Author), Masaki Otagiri (Author)
• Format: Book
• Published: MDPI AG, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In a previous study, we reported on the development of a synthetic polymer conjugate of pirarubicin (THP) that was formed via an acid-labile hydrazone bond between the polymer and the THP. However, the synthetic polymer itself was non-biodegradable, which could lead to unexpected adverse effects. Hu...