Synthesis and In Vitro Assessment of pH-Sensitive Human Serum Albumin Conjugates of Pirarubicin

• Hauptverfasser: Kenji Tsukigawa (Verfasst von), Shuhei Imoto (Verfasst von), Keishi Yamasaki (Verfasst von), Koji Nishi (Verfasst von), Toshihiko Tsutsumi (Verfasst von), Shoko Yokoyama (Verfasst von), Yu Ishima (Verfasst von), Masaki Otagiri (Verfasst von)
• Format: Buch
• Veröffentlicht: MDPI AG, 2020-12-01T00:00:00Z.
• Schlagworte: article
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In a previous study, we reported on the development of a synthetic polymer conjugate of pirarubicin (THP) that was formed via an acid-labile hydrazone bond between the polymer and the THP. However, the synthetic polymer itself was non-biodegradable, which could lead to unexpected adverse effects. Hu...