Physiologically Based Pharmacokinetic Modelling for Nicotine and Cotinine Clearance in Pregnant Women

• Main Authors: Basile Amice (Author), Harvey Ho (Author), En Zhang (Author), Chris Bullen (Author)
• 格式: 图书
• 出版: Frontiers Media S.A., 2021-07-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

Introduction: Physiologically based pharmacokinetic (PBPK) models for the absorption, disposition, metabolism and excretion (ADME) of nicotine and its major metabolite cotinine in pregnant women (p-PBPK) are rare. The aim of this short research report is to present a p-PBPK model and its simulations...