Impact of Tigecycline Versus Other Antibiotics on the Fecal Metabolome and on Colonization Resistance to Clostridium difficile in Mice

• Main Authors: Robin L.P. Jump (Author), David Kraft (Author), Kelly Hurless (Author), Alex Polinkovsky (Author), Curtis J. Donskey (Author)
• Format: Book
• Published: Case Western Reserve University, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: The glycylcycline antibiotic tigecycline may have a relatively low propensity to promote Clostridium difficile infection in part because it causes less disruption of the indigenous intestinal microbiota than other broad-spectrum antibiotics.  We used a mouse model to compare the compare...