Impact of Tigecycline Versus Other Antibiotics on the Fecal Metabolome and on Colonization Resistance to Clostridium difficile in Mice

• Egile Nagusiak: Robin L.P. Jump (Egilea), David Kraft (Egilea), Kelly Hurless (Egilea), Alex Polinkovsky (Egilea), Curtis J. Donskey (Egilea)
• Formatua: Liburua
• Argitaratua: Case Western Reserve University, 2017-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Background: The glycylcycline antibiotic tigecycline may have a relatively low propensity to promote Clostridium difficile infection in part because it causes less disruption of the indigenous intestinal microbiota than other broad-spectrum antibiotics.  We used a mouse model to compare the compare...