Liver-specific insulin receptor isoform A expression enhances hepatic glucose uptake and ameliorates liver steatosis in a mouse model of diet-induced obesity

• Main Authors: Andrea Raposo Lopez-Pastor (Author), Almudena Gomez-Hernandez (Author), Sabela Diaz-Castroverde (Author), Gloria Gonzalez-Aseguinolaza (Author), Agueda Gonzalez-Rodriguez (Author), Gema Garcia (Author), Silvia Fernandez (Author), Oscar Escribano (Author), Manuel Benito (Author)
• Format: Book
• Published: The Company of Biologists, 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Among the main complications associated with obesity are insulin resistance and altered glucose and lipid metabolism within the liver. It has previously been described that insulin receptor isoform A (IRA) favors glucose uptake and glycogen storage in hepatocytes compared with isoform B (IRB), impro...