Stemness-Attenuating miR-503-3p as a Paracrine Factor to Regulate Growth of Cancer Stem Cells

• Main Authors: Minkoo Seo (Author), Seung Min Kim (Author), Eun Young Woo (Author), Ki-Cheol Han (Author), Eun Joo Park (Author), Seongyeol Ko (Author), Eun wook Choi (Author), Mihue Jang (Author)
• Format: Book
• Published: Hindawi Limited, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cancer stem cells (CSCs) with self-renewal abilities endorse cellular heterogeneity, resulting in metastasis and recurrence. However, there are no promising therapeutics directed against CSCs. Herein, we found that miR-503-3p inhibited tumor growth via the regulation of CSC proliferation and self-re...