pH-Responsive and Mucoadhesive Nanoparticles for Enhanced Oral Insulin Delivery: The Effect of Hyaluronic Acid with Different Molecular Weights

• Autori principali: Shuangqing Wang (Autore), Saige Meng (Autore), Xinlei Zhou (Autore), Zhonggao Gao (Autore), Ming Guan Piao (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2023-03-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Drug degradation at low pH and rapid clearance from intestinal absorption sites are the main factors limiting the development of oral macromolecular delivery systems. Based on the pH responsiveness and mucosal adhesion of hyaluronic acid (HA) and poly[2-(dimethylamino)ethyl methacrylate] (PDM), we p...