pH-Responsive and Mucoadhesive Nanoparticles for Enhanced Oral Insulin Delivery: The Effect of Hyaluronic Acid with Different Molecular Weights

• मुख्य लेखकों: Shuangqing Wang (लेखक), Saige Meng (लेखक), Xinlei Zhou (लेखक), Zhonggao Gao (लेखक), Ming Guan Piao (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2023-03-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Drug degradation at low pH and rapid clearance from intestinal absorption sites are the main factors limiting the development of oral macromolecular delivery systems. Based on the pH responsiveness and mucosal adhesion of hyaluronic acid (HA) and poly[2-(dimethylamino)ethyl methacrylate] (PDM), we p...