Clinical Potential of Hypoxia Inducible Factors Prolyl Hydroxylase Inhibitors in Treating Nonanemic Diseases

• المؤلفون الرئيسيون: Mengqiu Miao (مؤلف), Mengqiu Wu (مؤلف), Yuting Li (مؤلف), Lingge Zhang (مؤلف), Qianqian Jin (مؤلف), Jiaojiao Fan (مؤلف), Xinyue Xu (مؤلف), Ran Gu (مؤلف), Haiping Hao (مؤلف), Aihua Zhang (مؤلف), Zhanjun Jia (مؤلف)
• التنسيق: كتاب
• منشور في: Frontiers Media S.A., 2022-02-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Hypoxia inducible factors (HIFs) and their regulatory hydroxylases the prolyl hydroxylase domain enzymes (PHDs) are the key mediators of the cellular response to hypoxia. HIFs are normally hydroxylated by PHDs and degraded, while under hypoxia, PHDs are suppressed, allowing HIF-α to accumulate and t...