Clinical Potential of Hypoxia Inducible Factors Prolyl Hydroxylase Inhibitors in Treating Nonanemic Diseases

• Main Authors: Mengqiu Miao (Author), Mengqiu Wu (Author), Yuting Li (Author), Lingge Zhang (Author), Qianqian Jin (Author), Jiaojiao Fan (Author), Xinyue Xu (Author), Ran Gu (Author), Haiping Hao (Author), Aihua Zhang (Author), Zhanjun Jia (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hypoxia inducible factors (HIFs) and their regulatory hydroxylases the prolyl hydroxylase domain enzymes (PHDs) are the key mediators of the cellular response to hypoxia. HIFs are normally hydroxylated by PHDs and degraded, while under hypoxia, PHDs are suppressed, allowing HIF-α to accumulate and t...