Design, synthesis and molecular docking of novel diarylcyclohexenone and diarylindazole derivatives as tubulin polymerization inhibitors

• Main Authors: Riham I. Ahmed (Author), Essam Eldin A. Osman (Author), Fadi M. Awadallah (Author), Samir M. El-Moghazy (Author)
• 格式: 图书
• 出版: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

New target compounds were designed as inhibitors of tubulin polymerization relying on using two types of ring B models (cyclohexenone and indazole) to replace the central ring in colchicine. Different functional groups (R1) were attached to manipulate their physicochemical properties and/or their bi...