Miconazole protects blood vessels from MMP9-dependent rupture and hemorrhage

• Главные авторы: Ran Yang (Автор), Yunpei Zhang (Автор), Dandan Huang (Автор), Xiao Luo (Автор), Liangren Zhang (Автор), Xiaojun Zhu (Автор), Xiaolin Zhang (Автор), Zhenming Liu (Автор), Jing-Yan Han (Автор), Jing-Wei Xiong (Автор)
• Формат: ‌
• Опубликовано: The Company of Biologists, 2017-03-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

Hemorrhagic stroke accounts for 10-15% of all strokes and is strongly associated with mortality and morbidity worldwide, but its prevention and therapeutic interventions remain a major challenge. Here, we report the identification of miconazole as a hemorrhagic suppressor by a small-molecule screen...