Miconazole protects blood vessels from MMP9-dependent rupture and hemorrhage

• Main Authors: Ran Yang (Author), Yunpei Zhang (Author), Dandan Huang (Author), Xiao Luo (Author), Liangren Zhang (Author), Xiaojun Zhu (Author), Xiaolin Zhang (Author), Zhenming Liu (Author), Jing-Yan Han (Author), Jing-Wei Xiong (Author)
• Format: Book
• Published: The Company of Biologists, 2017-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hemorrhagic stroke accounts for 10-15% of all strokes and is strongly associated with mortality and morbidity worldwide, but its prevention and therapeutic interventions remain a major challenge. Here, we report the identification of miconazole as a hemorrhagic suppressor by a small-molecule screen...