PLGA Nanoparticles Loaded with Sorafenib Combined with Thermosensitive Hydrogel System and Microwave Hyperthermia for Multiple Sensitized Radiotherapy

• المؤلفون الرئيسيون: Ziqi Wang (مؤلف), Bo Liu (مؤلف), Jingyao Tu (مؤلف), Jingfeng Xiang (مؤلف), Hui Xiong (مؤلف), Yue Wu (مؤلف), Shuaijie Ding (مؤلف), Daoming Zhu (مؤلف), Dongyong Zhu (مؤلف), Fei Liu (مؤلف), Guangyuan Hu (مؤلف), Xianglin Yuan (مؤلف)
• التنسيق: كتاب
• منشور في: MDPI AG, 2023-02-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Hypoxia is typically the leading cause of radiotherapy (RT) resistance in solid tumors, and glutathione (GSH) overexpression in tumor cells is a potent antioxidant mechanism that protects tumor cells from radiation damage. Herein, we developed a sorafenib (SFN) loaded-PLGA hydrogel system (SPH) in c...