PLGA Nanoparticles Loaded with Sorafenib Combined with Thermosensitive Hydrogel System and Microwave Hyperthermia for Multiple Sensitized Radiotherapy

• Main Authors: Ziqi Wang (Author), Bo Liu (Author), Jingyao Tu (Author), Jingfeng Xiang (Author), Hui Xiong (Author), Yue Wu (Author), Shuaijie Ding (Author), Daoming Zhu (Author), Dongyong Zhu (Author), Fei Liu (Author), Guangyuan Hu (Author), Xianglin Yuan (Author)
• Format: Book
• Published: MDPI AG, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hypoxia is typically the leading cause of radiotherapy (RT) resistance in solid tumors, and glutathione (GSH) overexpression in tumor cells is a potent antioxidant mechanism that protects tumor cells from radiation damage. Herein, we developed a sorafenib (SFN) loaded-PLGA hydrogel system (SPH) in c...