Conformational Equilibrium of NADPH-Cytochrome P450 Oxidoreductase Is Essential for Heme Oxygenase Reaction

• Príomhchruthaitheoirí: Masakazu Sugishima (Údar), Junichi Taira (Údar), Tatsuya Sagara (Údar), Ryota Nakao (Údar), Hideaki Sato (Údar), Masato Noguchi (Údar), Keiichi Fukuyama (Údar), Ken Yamamoto (Údar), Takuo Yasunaga (Údar), Hiroshi Sakamoto (Údar)
• Formáid: LEABHAR
• Foilsithe / Cruthaithe: MDPI AG, 2020-07-01T00:00:00Z.
• Ábhair: article
• Rochtain ar líne: Connect to this object online.

Heme oxygenase (HO) catalyzes heme degradation using electrons supplied by NADPH-cytochrome P450 oxidoreductase (CPR). Electrons from NADPH flow first to FAD, then to FMN, and finally to the heme in the redox partner. Previous biophysical analyses suggest the presence of a dynamic equilibrium betwee...