Conformational Equilibrium of NADPH-Cytochrome P450 Oxidoreductase Is Essential for Heme Oxygenase Reaction

• Үндсэн зохиолчид: Masakazu Sugishima (Зохиогч), Junichi Taira (Зохиогч), Tatsuya Sagara (Зохиогч), Ryota Nakao (Зохиогч), Hideaki Sato (Зохиогч), Masato Noguchi (Зохиогч), Keiichi Fukuyama (Зохиогч), Ken Yamamoto (Зохиогч), Takuo Yasunaga (Зохиогч), Hiroshi Sakamoto (Зохиогч)
• Формат: Ном
• Хэвлэсэн: MDPI AG, 2020-07-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Heme oxygenase (HO) catalyzes heme degradation using electrons supplied by NADPH-cytochrome P450 oxidoreductase (CPR). Electrons from NADPH flow first to FAD, then to FMN, and finally to the heme in the redox partner. Previous biophysical analyses suggest the presence of a dynamic equilibrium betwee...