Conformational Equilibrium of NADPH-Cytochrome P450 Oxidoreductase Is Essential for Heme Oxygenase Reaction

• Hoofdauteurs: Masakazu Sugishima (Auteur), Junichi Taira (Auteur), Tatsuya Sagara (Auteur), Ryota Nakao (Auteur), Hideaki Sato (Auteur), Masato Noguchi (Auteur), Keiichi Fukuyama (Auteur), Ken Yamamoto (Auteur), Takuo Yasunaga (Auteur), Hiroshi Sakamoto (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2020-07-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Heme oxygenase (HO) catalyzes heme degradation using electrons supplied by NADPH-cytochrome P450 oxidoreductase (CPR). Electrons from NADPH flow first to FAD, then to FMN, and finally to the heme in the redox partner. Previous biophysical analyses suggest the presence of a dynamic equilibrium betwee...