Synthesis, Antimalarial, Antileishmanial, and Cytotoxicity Activities and Preliminary In Silico ADMET Studies of 2-(7-Chloroquinolin-4-ylamino)ethyl Benzoate Derivatives

• Main Authors: Joyce E. Gutiérrez (Author), Hegira Ramírez (Author), Esteban Fernandez-Moreira (Author), María E. Acosta (Author), Michael R. Mijares (Author), Juan Bautista De Sanctis (Author), Soňa Gurská (Author), Petr Džubák (Author), Marián Hajdúch (Author), Liesangerli Labrador-Fagúndez (Author), Bruno G. Stella (Author), Luis José Díaz-Pérez (Author), Gustavo Benaim (Author), Jaime E. Charris (Author)
• Format: Book
• Published: MDPI AG, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of heterocyclic chloroquine hybrids, containing a chain of two carbon atoms at position four of the quinolinic chain and acting as a link between quinoline and several benzoyl groups, is synthesized and screened in vitro as an inhibitor of β-hematin formation and in vivo for its antimalaria...