Omeprazole Prevents Colistin-Induced Nephrotoxicity in Rats: Emphasis on Oxidative Stress, Inflammation, Apoptosis and Colistin Accumulation in Kidneys

• Main Authors: Mohammed Z. Nasrullah (Author), Khalid Eljaaly (Author), Thikryat Neamatallah (Author), Usama A. Fahmy (Author), Abdulmohsin J. Alamoudi (Author), Hussain T. Bakhsh (Author), Ashraf B. Abdel-Naim (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The clinical value of colistin, a polymyxin antibiotic, is limited by its nephrotoxicity. Omeprazole is a commonly prescribed proton pump inhibitor. The current study aimed to evaluate the effects of the concomitant administration of omeprazole on colistin-induced nephrotoxicity in rats. Omeprazole...