Radiosynthesis and preclinical evaluation of a 68Ga-labeled tetrahydroisoquinoline-based ligand for PET imaging of C-X-C chemokine receptor type 4 in an animal model of glioblastoma

Radiosynthesis and preclinical evaluation of a 68Ga-labeled tetrahydroisoquinoline-based ligand for PET imaging of C-X-C chemokine receptor type 4 in an animal model of glioblastoma

Abstract Background This study aimed to develop a novel positron emission tomography (PET) tracer, [68Ga]Ga-TD-01, for CXCR4 imaging. To achieve this goal, the molecular scaffold of TIQ15 was tuned by conjugation with the DOTA chelator to make it suitable for 68Ga radiolabeling. Methods A bifunction...

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Main Authors: Piyapan Suwattananuruk (Author), Sukanya Yaset (Author), Chanisa Chotipanich (Author), Angel Moldes-Anaya (Author), Rune Sundset (Author), Rodrigo Berzaghi (Author), Stine Figenschau (Author), Sandra Claes (Author), Dominique Schols (Author), Pornchai Rojsitthisak (Author), Mathias Kranz (Author), Opa Vajragupta (Author)
Format: Book
Published: SpringerOpen, 2024-08-01T00:00:00Z.
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