Radiosynthesis and preclinical evaluation of a 68Ga-labeled tetrahydroisoquinoline-based ligand for PET imaging of C-X-C chemokine receptor type 4 in an animal model of glioblastoma

• Päätekijät: Piyapan Suwattananuruk (Tekijä), Sukanya Yaset (Tekijä), Chanisa Chotipanich (Tekijä), Angel Moldes-Anaya (Tekijä), Rune Sundset (Tekijä), Rodrigo Berzaghi (Tekijä), Stine Figenschau (Tekijä), Sandra Claes (Tekijä), Dominique Schols (Tekijä), Pornchai Rojsitthisak (Tekijä), Mathias Kranz (Tekijä), Opa Vajragupta (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: SpringerOpen, 2024-08-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Abstract Background This study aimed to develop a novel positron emission tomography (PET) tracer, [68Ga]Ga-TD-01, for CXCR4 imaging. To achieve this goal, the molecular scaffold of TIQ15 was tuned by conjugation with the DOTA chelator to make it suitable for 68Ga radiolabeling. Methods A bifunction...