Geranylgeranyl pyrophosphate depletion by statins compromises skeletal muscle insulin sensitivity

• Egile Nagusiak: Lai Wang (Egilea), Zuguo Zheng (Egilea), Lijun Zhu (Egilea), Lingchang Meng (Egilea), Hanling Liu (Egilea), Keke Wang (Egilea), Jun Chen (Egilea), Ping Li (Egilea), Hua Yang (Egilea)
• Formatua: Liburua
• Argitaratua: Wiley, 2022-12-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Abstract Background Statins are widely prescribed cholesterol‐lowering drugs but have been shown to increase the risk of type 2 diabetes mellitus. However, the molecular mechanisms underlying the diabetogenic effect of statins are still not fully understood. Methods The effects of geranylgeranyl tra...