Geranylgeranyl pyrophosphate depletion by statins compromises skeletal muscle insulin sensitivity

• Main Authors: Lai Wang (Author), Zuguo Zheng (Author), Lijun Zhu (Author), Lingchang Meng (Author), Hanling Liu (Author), Keke Wang (Author), Jun Chen (Author), Ping Li (Author), Hua Yang (Author)
• Format: Book
• Published: Wiley, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Statins are widely prescribed cholesterol‐lowering drugs but have been shown to increase the risk of type 2 diabetes mellitus. However, the molecular mechanisms underlying the diabetogenic effect of statins are still not fully understood. Methods The effects of geranylgeranyl tra...