Toosendanin, a late-stage autophagy inhibitor, sensitizes triple-negative breast cancer to irinotecan chemotherapy

• Главные авторы: Shuang Zhang (Автор), Yu Dong (Автор), Xiuping Chen (Автор), Chris Soon Heng TAN (Автор), Min Li (Автор), Kai Miao (Автор), Jia-Hong Lu (Автор)
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• Опубликовано: BMC, 2022-05-01T00:00:00Z.
• Предметы: article
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Abstract Background Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer that develops resistance to chemotherapy frequently. Autophagy has been reported as a pro-survival response to chemotherapeutic drugs in TNBC, and suppression of autophagy can be a strategy to ov...