A natural compound-empowered podophyllotoxin prodrug nanoassembly magnifies efficacy-toxicity benefits in cancer chemotherapy

• Main Authors: Ziqi Lin (Author), Yuequan Wang (Author), Wenwen Li (Author), Fei Sun (Author), Qingzhi Lv (Author), Shenwu Zhang (Author), Xiaohong Liu (Author), Feng Qin (Author), Cong Luo (Author)
• Format: Book
• Published: Elsevier, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Small-molecule prodrug nanoassembly technology with a unique advantage in off-target toxicity reduction has been widely used for antitumor drug delivery. However, prodrug activation remains a rate-limiting step for exerting therapeutic actions, which requires to quickly reach the minimum valid conce...