A natural compound-empowered podophyllotoxin prodrug nanoassembly magnifies efficacy-toxicity benefits in cancer chemotherapy

• Prif Awduron: Ziqi Lin (Awdur), Yuequan Wang (Awdur), Wenwen Li (Awdur), Fei Sun (Awdur), Qingzhi Lv (Awdur), Shenwu Zhang (Awdur), Xiaohong Liu (Awdur), Feng Qin (Awdur), Cong Luo (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Elsevier, 2024-08-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Small-molecule prodrug nanoassembly technology with a unique advantage in off-target toxicity reduction has been widely used for antitumor drug delivery. However, prodrug activation remains a rate-limiting step for exerting therapeutic actions, which requires to quickly reach the minimum valid conce...